Which systemic drug is commonly used to treat severe symptoms of asthma?

Oral corticosteroids are commonly used to treat severe symptoms of asthma because they have potent anti-inflammatory effects that can quickly reduce airway inflammation, thereby alleviating symptoms. In cases of acute exacerbations or severe asthma attacks, systemic corticosteroids such as prednisone are often prescribed to manage inflammation and improve respiratory function. These medications work by suppressing the immune response and decreasing the release of inflammatory mediators, which is crucial in severe asthma episodes when the airways are significantly constricted and inflamed.

While inhalable corticosteroids, short-acting beta agonists, and combination inhalers are important in managing asthma, they are typically used in different contexts. Inhalable corticosteroids are primarily used for long-term control and prevention of asthma symptoms, while short-acting beta agonists are mainly for quick relief of acute symptoms. Combination inhalers are designed for ongoing management but do not provide the rapid anti-inflammatory effect needed in severe situations like oral corticosteroids do. Thus, oral corticosteroids are the appropriate choice for addressing severe asthma symptoms.