Which of the following is true regarding the risks associated with opioid use?

The statement that opioids can lead to overdose is accurate and highlights one of the significant risks associated with their use. Opioids are powerful analgesics that can effectively manage pain, but they also carry a high potential for abuse and dependency. When taken in higher doses than prescribed or mixed with other substances, particularly depressants like alcohol, they can depress the respiratory system, leading to potentially fatal respiratory failure.

Understanding the context of the other statements assists in appreciating why the possibility of overdose is a critical concern. Opioids are indeed addictive (contrary to the notion of being non-addictive) and can lead to physical dependence and withdrawal symptoms. Long-term use often necessitates careful monitoring due to the risks of tolerance (requiring higher doses to achieve the same effect) and the development of misuse patterns. Additionally, while opioids are effective for pain relief, they should not be viewed as universally effective for all types of pain nor without regard for the risks involved. With these considerations, the assertion regarding the potential for overdose remains a fundamental aspect of opioid pharmacology that cannot be overlooked.