Which of the following is a common side effect of NSAIDs?

A common side effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is stomach upset, which can manifest as gastric irritation, pain, nausea, or even ulcers. NSAIDs work by inhibiting enzymes involved in the inflammatory process, specifically cyclooxygenase (COX), which also play a role in protecting the gastric lining. When these enzymes are inhibited, the protective mucus layer in the stomach can diminish, leading to irritation of the stomach lining and creating discomfort.

Gingival hyperplasia, commonly associated with certain anticonvulsants or calcium channel blockers, is not a typical side effect of NSAIDs. Xerostomia, or dry mouth, is also not widely recognized as a direct effect of NSAIDs, although some individuals may experience it. High blood pressure is not a primary side effect of NSAIDs, though prolonged use may potentially contribute to hypertension in some individuals due to fluid retention or kidney effects.

Thus, the mechanism of action for NSAIDs and their impact on the gastrointestinal system makes stomach upset a quintessential side effect.