Which of the following is a norepinephrine and dopamine reuptake inhibitor (NDRI)?

Wellbutrin, which is the brand name for bupropion, is classified as a norepinephrine and dopamine reuptake inhibitor (NDRI). This means that it works by blocking the reuptake of norepinephrine and dopamine neurotransmitters in the brain, thereby increasing their levels and promoting mood enhancement. Bupropion is often used to treat major depressive disorder and is also utilized as a smoking cessation aid.

The other medications listed do not share this mechanism of action. Nardil, for instance, is a monoamine oxidase inhibitor (MAOI) that works differently by preventing the breakdown of monoamines in the brain. Elavil is the brand name for amitriptyline, a tricyclic antidepressant that primarily influences serotonin and norepinephrine reuptake but does not have a distinct NDRI classification. Prozac, or fluoxetine, is a selective serotonin reuptake inhibitor (SSRI), which specifically targets serotonin levels without significantly affecting norepinephrine or dopamine. Thus, Wellbutrin is the unique choice that aligns with the NDRI classification.