Which antibiotic is considered the premedication of choice for patients with hip or joint replacements?

The antibiotic that is considered the premedication of choice for patients with hip or joint replacements is a cephalosporin. This recommendation is based on its broad-spectrum activity against common pathogens that could cause infections, especially in patients with prosthetic joints. Cephalosporins have a good safety profile and are effective in preventing bacterial endocarditis and other infections that can arise from dental procedures.

In the context of patients with hip or joint replacements, premedication is crucial to prevent infections due to the introduction of bacteria during dental procedures. Cephalosporins, particularly those like cephalexin, provide effective coverage against skin flora, which is a common concern for such infections.

The other antibiotics listed do not have the same level of recommendation or effectiveness for this specific purpose. Tetracyclines are generally not the first choice for prophylaxis and are typically used for different types of infections. Metronidazole is aimed primarily at anaerobic bacteria and protozoal infections, which are not the primary concern in this scenario. Penicillin is effective but may not be the best choice for patients with a history of allergy or for the specific prophylactic needs associated with joint replacements, as cephalosporins are often preferred for