Which antibiotic can cause C. difficile infection and is treated with Vancomycin and/or Metronidazole?

Clindamycin is known to disrupt the normal gastrointestinal flora, which can predispose individuals to Clostridium difficile (C. difficile) infection. This antibiotic, particularly when used in higher doses or for prolonged periods, can lead to an overgrowth of C. difficile, resulting in antibiotic-associated diarrhea or more severe colitis.

When managing a C. difficile infection, treatment options include Vancomycin and Metronidazole, which are effective against this specific pathogen. These antibiotics help re-establish the normal gut flora by targeting the C. difficile bacteria directly. Other antibiotics listed, such as macrolides, penicillin, and amoxicillin, are significantly less associated with C. difficile infections, making clindamycin the key concern in this context.