Which agent is used to lower triglyceride levels specifically?

Simvastatin is specifically indicated for lowering triglyceride levels as part of its effects on lipid metabolism. It is classified as a statin, which works by inhibiting HMG-CoA reductase, an enzyme pivotal in the synthesis of cholesterol in the liver. By reducing the production of cholesterol, statins also lead to a decrease in triglyceride levels in the bloodstream, alongside an increase in high-density lipoprotein (HDL) levels, which is beneficial for cardiovascular health.

Other agents listed do not primarily target triglyceride reduction. Metformin is primarily used for managing blood glucose in type 2 diabetes and has minimal effects on triglyceride levels. Glipizide, another antidiabetic medication, stimulates insulin secretion but does not directly lower triglycerides. Insulin is critical for glucose metabolism but is not specifically used to lower triglycerides; in some cases, high doses of insulin can actually lead to increased triglyceride levels. Therefore, simvastatin stands out as the correct choice for specifically addressing high triglyceride levels.