What is the term for a drug administered via the rectum that also avoids the first pass effect?

The term for a drug administered via the rectum that also avoids the first pass effect is rectal. This route of administration is particularly effective because medications given rectally can be absorbed through the rectal mucosa and enter the systemic circulation. Unlike oral medications, which pass through the liver before reaching systemic circulation due to the first pass effect, rectal medications can partially bypass the liver, reducing the metabolism of the drug before it reaches its site of action. This can lead to enhanced bioavailability and effectiveness of the drug.

While sublingual medications also avoid the first pass effect, they are taken under the tongue, which is different from the rectal route. Oral medications are subject to the first pass effect as they are metabolized by the liver after oral ingestion. Intramuscular administration allows for direct entry into the bloodstream but does not specifically utilize the rectal route and also does not avoid the first pass effect in the same way as rectal administration.