What is the main substance produced by the enzyme inhibited by ACE inhibitors?

The main substance produced by the enzyme inhibited by ACE inhibitors is Angiotensin II. ACE, or angiotensin-converting enzyme, is responsible for converting Angiotensin I, an inactive precursor, into Angiotensin II, which is a potent vasoconstrictor and plays a significant role in regulating blood pressure and fluid balance.

Inhibition of ACE prevents the formation of Angiotensin II, thereby leading to vasodilation and a reduction in blood pressure. This mechanism is crucial in the management of conditions such as hypertension and heart failure. The significance of Angiotensin II within the renin-angiotensin-aldosterone system highlights its impact on cardiovascular function, which is why ACE inhibitors are commonly prescribed in clinical settings.

Angiotensins I, III, and IV serve as different forms or products derived from this pathway, but it is Angiotensin II that is central to the effects of ACE inhibitors.