True or False: Anti-hyperlipidemic medications can safely be taken with grapefruit juice.

Anti-hyperlipidemic medications, particularly statins and certain others like simvastatin and atorvastatin, can interact negatively with grapefruit juice. Grapefruit contains compounds that inhibit the cytochrome P450 3A4 enzyme in the liver and intestines, which is responsible for metabolizing many medications, including statins. When ingestion of grapefruit juice occurs, it can lead to increased levels of the medication in the bloodstream, raising the risk of side effects or toxicity. Given this information, it is indeed considered unsafe to take these medications with grapefruit juice, making the statement false.

Alternative options might suggest that some medications can be taken with grapefruit juice, but in the context of anti-hyperlipidemic drugs, the inhibition of metabolism remains a significant concern, reinforcing that the answer is indeed false.