Overdose of NSAIDs may cause damage to which organ?

NSAID (non-steroidal anti-inflammatory drug) overdose can lead to significant damage to the kidneys. This stems from the way NSAIDs affect renal blood flow and glomerular filtration rate. They inhibit the production of prostaglandins, which are crucial in maintaining blood flow to the kidneys, especially during states of dehydration or compromised blood volume. In the setting of overdose, the inhibition of these protective mechanisms can result in acute kidney injury, electrolyte imbalances, and even renal failure.

While other organs such as the liver and pancreas can be affected by certain medications, in the context of NSAIDs, the kidneys are particularly vulnerable due to their reliance on prostaglandin-mediated mechanisms for proper function and hemodynamics. Therefore, an overdose of NSAIDs can lead to acute renal failure, making the kidneys the primary organ of concern.