Bupropion (Wellbutrin) belongs to which class of antidepressant?

Bupropion, marketed as Wellbutrin, is classified as a norepinephrine and dopamine reuptake inhibitor (NDRI). This classification is significant because bupropion uniquely targets the neurotransmitters norepinephrine and dopamine, which distinguishes it from other classes of antidepressants. Unlike monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, and tricyclic antidepressants, bupropion does not primarily focus on serotonin levels.

NDRIs can be particularly effective for individuals who may not respond well to traditional antidepressants or have specific symptoms such as fatigue or low energy. Bupropion is also noted for its minimal sexual side effects and can be used in smoking cessation therapy, highlighting its versatility in treating different conditions beyond depression. This mechanism of action is crucial for understanding its pharmacological profile and therapeutic uses.